Cyclophosphamide Injection 500 mg Single-Dose Vial by Long Grove (RX)Supply

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Cyclophosphamide for Injection is a chemotherapy medication used to treat various types of cancer, including leukemia, lymphoma, and breast cancer. It works by slowing or stopping the growth of cancer cells. As an alkylating agent, it interferes with the DNA replication of rapidly dividing tumor cells. Cyclophosphamide is administered intravenously under medical supervision, often as part of a combination chemotherapy regimen, to enhance its effectiveness and target a broader range of cancerous cells.

Cyclophosphamide is an alkylating agent offering robust anti-cancer properties, pivotal in the treatment regimens of various malignancies and autoimmune conditions. Delivered by Long Grove in a convenient 500 mg single-dose vial, this chemotherapeutic agent is designed to meet the rigorous demands of healthcare providers ensuring efficacy, safety, and consistency.

Product Details and Features

Product Name: Cyclophosphamide for Injection
Strength: 500 mg per single-dose vial
Manufacturer: Long Grove
Dosage Form: Sterile powder for reconstitution and intravenous or intramuscular administration
Packaging: Secure and sterile packaging to preserve potency and integrity until reconstitution
Indications: Primarily indicated for the treatment of malignant lymphomas, multiple myeloma, leukemia, mycosis fungoides, neuroblastoma, ovarian carcinoma, and breast carcinoma. Also used in conditioning regimens prior to bone marrow transplantation and in certain autoimmune disorders.
Storage Conditions: Store vials at controlled room temperature, 20°C to 25°C (68°F to 77°F). Protect from light.

Features

• Broad-spectrum Usage: Effective against a variety of cancer types and suitable for autoimmune conditions.
  
• Proven Clinical Efficacy: Well-documented results in oncology as a monotherapy or in combination regimens.
  
• Reliable Manufacturing: Produced by Long Grove, guaranteeing quality assurance in every vial.

Mechanism of Action

Cyclophosphamide functions as an alkylating agent by attaching an alkyl group to the DNA guanine base, leading to DNA cross-linking and strand breakage. This disrupts DNA replication and RNA transcription, inducing apoptosis in rapidly dividing tumor cells. While the primary impact is on cancer cells, high proliferation rates cause collateral damage to certain normal healthy cells, contributing to side effects typical of chemotherapy.

Directions for Use

1. Reconstitution: Aseptically reconstitute the 500 mg powder with an appropriate volume of Sterile Water for Injection (as indicated in product literature) to ensure complete dissolution.
2. Administration: Administer intravenously over a specified period or intramuscularly, taking care to consider the therapeutic regimen that may require dose adjustments based on patient tolerance and intended outcomes.
3. Dosage: Dosage is highly individualized according to type and stage of cancer, patient size, and regimen (monotherapy or combination therapy). Medical professionals should establish protocols.
4. Supervision: Therapy should be administered under the superintendency of a qualified medical professional experienced in cancer chemotherapy.

Warnings

• Bone Marrow Suppression: Monitor blood counts frequently as cyclophosphamide can induce leukopenia, thrombocytopenia, and anemia.
• Secondary Malignancies: Long-term use may risk developing secondary malignancies.
• Toxicity: Risks include cardiotoxicity at high dosages, potential liver toxicity.
• Hypersensitivity Reactions: Some patients may demonstrate hypersensitivity leading to adverse reactions.

Side Effects

While cyclophosphamide is often tolerated given its therapeutic importance, it may cause side effects:

• Common: Nausea, vomiting, alopecia, and fatigue.
• Serious: Hemorrhagic cystitis due to acrolein (a metabolite); requires adequate hydration and possibly mesna therapy for prevention.
• Immunosuppressive Effects: Increased risk of infection due to bone marrow suppression.
• Gastrointestinal and Dermatological: Mucosal damage and skin reactions.

Cyclophosphamide for Injection is a critical component in cancer therapy, with proven effectiveness across diverse malignancies. Always consult with healthcare professionals for suitability, dosage, and monitoring to optimize therapeutic outcomes while minimizing adverse effects. Trust Cyclophosphamide by Long Grove to be a cornerstone of effective oncological care.